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Itraconazole Capsule

Itraconazole Capsule
Itraconazole Capsule
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Product Code : 11
Brand Name : YITRA
Price And Quantity
Product Specifications
  • Formulations Type
  • Other Types
Product Description

Itraconazole Capsule is antifungal medicine which is indicated for treating aspergillosis, blastomycosis, and coccidiomycosis. It is highly effective in nature and is known to work by inhibiting ergosterol synthesis which causes fungal dearth. Active compound present in this medicine has molecular formula C35H38Cl2N8O4 with molar mass of 705.64 g/mol. It is metabolized in liver with help of CYP3A4 and shows protein binding ability of 99.8%. Itraconazole Capsule exerts its activity by inhibiting lanosterol 14-alpha-demethylase enzyme.

Features:

  • Belongs to triazole medicine family
  • Fast mode of action
  • Disrupts cell membrane of fungi to fight infections

 

 

Monograph

MedlinePlus

a692049

Pregnancy
category

  • AU: B3
  • US: C (Risk not ruled out)

 

Routes of
administration

By mouth (capsulessolution), local (vaginal suppository), IV; By mouth only (UK and US)

ATC code

 

Legal status

Legal status

 

Pharmacokinetic data

Bioavailability

~55%, maximal if taken with full meal

Protein binding

99.8%

Metabolism

Extensive in liver (CYP3A4)

Metabolites

Hydroxy-itraconazole, keto-itraconazole,
N-desalkyl-itraconazole
[1]

Elimination half-life

21 hours

Excretion

Urine (35%), faeces (54%)[2]

Identifiers

IUPAC name[show]

CAS Number

 

PubChem CID

 

DrugBank

 

ChemSpider

 

UNII

 

KEGG

 

ChEBI

 

ChEMBL

 

ECHA InfoCard

100.123.596 Edit this at Wikidata

Chemical and physical data

Formula

C35H38Cl2N8O4

Molar mass

705.64

3D model (JSmol)

 

Chirality

Racemic mixture

SMILES[show]

InChI[show]

  (verify)

Itraconazole is an antifungal medication used to treat a number of fungal infections.[3] This includes aspergillosisblastomycosiscoccidioidomycosishistoplasmosis, and paracoccidioidomycosis.[3] It may be given by mouth or intravenously.[3]

Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.[3] Severe side effects may include liver problemsheart failureStevens-Johnson syndrome and allergic reactions including anaphylaxis.[3] It is unclear if use during pregnancy or breastfeeding is safe.[4] It is in the triazole family of medications.[3] It stops fungal growth by affecting the cell membrane or affecting their metabolism

 

Trade Information
  • Delivery Time
  • 3-7 Days
  • Sample Policy
  • Sample costs shipping and taxes has to be paid by the buyer
  • Packaging Details
  • 10*1*4 BLISTER
  • Main Export Market(s)
  • Asia
  • Main Domestic Market
  • All India

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