Itraconazole Capsule

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Product Code : 11

Brand Name : YITRA

Product Description

Itraconazole Capsule is antifungal medicine which is indicated for treating aspergillosis, blastomycosis, and coccidiomycosis. It is highly effective in nature and is known to work by inhibiting ergosterol synthesis which causes fungal dearth. Active compound present in this medicine has molecular formula C35H38Cl2N8O4 with molar mass of 705.64 g/mol. It is metabolized in liver with help of CYP3A4 and shows protein binding ability of 99.8%. Itraconazole Capsule exerts its activity by inhibiting lanosterol 14-alpha-demethylase enzyme.

Features:

Belongs to triazole medicine family
Fast mode of action
Disrupts cell membrane of fungi to fight infections

Monograph
MedlinePlus	a692049
Pregnancy category	AU: B3 US: C (Risk not ruled out)
Routes of administration	By mouth (capsules, solution), local (vaginal suppository), IV; By mouth only (UK and US)
ATC code	J02AC02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: Ã¢â€žÅ¾-only UK: POM (Prescription only) US: Ã¢â€žÅ¾-only
Pharmacokinetic data
Bioavailability	~55%, maximal if taken with full meal
Protein binding	99.8%
Metabolism	Extensive in liver (CYP3A4)
Metabolites	Hydroxy-itraconazole, keto-itraconazole, N-desalkyl-itraconazole^[1]
Elimination half-life	21 hours
Excretion	Urine (35%), faeces (54%)^[2]
Identifiers
IUPAC name [show]
CAS Number	84625-61-6
PubChem CID	55283
DrugBank	DB01167
ChemSpider	49927
UNII	304NUG5GF4
KEGG	D00350
ChEBI	CHEBI:6076
ChEMBL	CHEMBL22587
ECHA InfoCard	100.123.596
Chemical and physical data
Formula	C₃₅H₃₈Cl₂N₈O₄
Molar mass	705.64
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES [show]
InChI [show]
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Itraconazole is an antifungal medication used to treat a number of fungal infections.^[3] This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis.^[3] It may be given by mouth or intravenously.^[3]

Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.^[3] Severe side effects may include liver problems, heart failure, Stevens-Johnson syndrome and allergic reactions including anaphylaxis.^[3] It is unclear if use during pregnancy or breastfeeding is safe.^[4] It is in the triazole family of medications.^[3] It stops fungal growth by affecting the cell membrane or affecting their metabolism

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